Biologics & PTOA Research Grant (Sponsored by RTI Surgical)

The American Orthopaedic Society for Sports Medicine (AOSSM), under the auspices of its Research Committee, is offering one grant of up to $250,000 to support a clinical, translational, or laboratory-based research project investigating post-traumatic osteoarthritis of the major peripheral joints (knee, shoulder, hip, ankle, elbow)

Post-traumatic osteoarthritis represents a significant public health concern and is one of the common denominators to sports injuries affecting all parts of the body, often despite adequate surgical treatment of the initial injury. While extensive research has been funded through AOSSM to improve the short to mid-term outcomes after sports injuries (return to sport, 2- year patient reported outcomes, etc.), the current funding mechanism is specifically designed to support studies that investigate the pathophysiology, prevention, treatment or long-term repercussion of post-traumatic osteoarthritis and the role of biologics in PTOA. The mechanism is not intended to be joint specific, and studies that would have implications for multiple joints or sub-disciplines of sports medicine will be considered favorably. Additionally, collaborative studies that bring clinician-scientists and laboratory scientists together towards a common aim are strongly encouraged.

To begin the application process, please review the guidelines specific to this grant, below. Next, visit our submission center to start your application. Projects aligning with the following research priorities are encouraged:
• Studies that investigate the definition of PTOA: laboratory criteria, radiographic/imaging criteria, clinical criteria, classification or stratification schemes.
• Studies that investigate serological or synovial biomarkers that can predict the occurrence or severity of PTOA.
• Studies that investigate the role of advanced imaging (including but not limited to MRI based assessments of cartilage health such as T1p or T2-mapping) in the diagnosis, prognostication or monitoring of PTOA.
• Studies that investigate the use of artificial intelligence or machine learning for the development of high throughput imaging analysis for PTOA.
• Studies that investigate image-based scoring systems for PTOA.
• Studies that investigate the value of legacy patient reported outcomes (KOOS, IKDC, etc.) in the clinical assessment of PTOA.
• Studies that investigate and/or validate novel PROs for the clinical assessment of PTOA.
• Studies that investigate the role of the meniscus in PTOA, including studies of meniscal substitution(including novel tissue engineered or synthetic options) / meniscal transplantation and their role in preventing or mitigating PTOA.
• Studies that investigate the role of ligamentous injury and/or reconstruction in the prevention/modulation of PTOA.
• Studies that investigate therapeutic interventions after ligamentous injury to prevent / modulate PTOA.
• Studies that establish and/or utilize small or large animal models of PTOA to further our understanding of PTOA pathophysiology, natural history and treatment options.
• Studies that utilize animal models to explore biologics, stem cell therapies or gene therapy for PTOA.
• Studies that utilize a regenerative medicine or tissue engineering approach to PTOA.
• Studies that set the groundwork for extramural funding proposals through the NIH or DOD will be considered favorably
• Studies that involve any of the major peripheral joints (post-instability glenohumeral PTOA, FAI-induced hip PTOA, ankle PTOA from chronic lateral instability are a few examples)

Actively Accepting Proposals:
Submission Center Link
Final Application Deadline: March 15, 2021

Available Application Downloads and Instructions

Biologics & PTOA Research Grant Guidelines
Biosketch Forms